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The Untapped Potential of Genetically Engineered Mouse Models in Chemoprevention Research: Opportunities and Challenges

Authors' Affiliations: ¹ Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons; ² Strang Cancer Prevention Center, Weill Medical College of Cornell University, New York, New York; ³ Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas; ⁴ Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland; ⁵ Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, Arizona; ⁶ Laboratory of Cancer Biology and Genomics, National Cancer Institute, Bethesda, Maryland; ⁷ Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland; and ⁸ Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina

Requests for reprints: Cory Abate-Shen, Herbert Irving Comprehensive Cancer Center, Room 217A, 1130 St. Nicholas Street, New York, NY 10032. Phone: 212-851-4731; Fax: 212-851-4572; E-mail: cabateshen{at}columbia.edu.

The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.

Key Words: chemoprevention • mouse models • review