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Clinical Prevention of Recurrence of Colorectal Adenomas by the Combination of Difluoromethylornithine and Sulindac: An Important Milestone

Authors' Affiliations: ¹ Department of Pharmacology, Dartmouth Medical School, Hanover, New Hamsphire, and ² Division of Cancer Medicine, M. D. Anderson Cancer Center, Houston, Texas

Correspondence: Requests for reprints: Michael B. Sporn, Department of Pharmacology, Dartmouth Medical School, 7650 Remsen, Hanover, NH 03755. Phone: 603-650-6557; Fax: 603-650-1129; E-mail: michael.sporn{at}dartmouth.edu.

Abstract

The spectacular clinical results reported by Meyskens, Gerner and colleagues in a lead article (1) of this very first issue of this new AACR journal on cancer prevention represent a landmark advance in efforts to stop the current worldwide epidemic of cancer deaths. This study also sets a new, exceptionally high standard for future clinical research on the chemoprevention of cancer.

Key Article

Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial

Frank L. Meyskens, Jr., Christine E. McLaren, Daniel Pelot, Sharon Fujikawa-Brooks, Philip M. Carpenter, Ernest Hawk, Gary Kelloff, Michael J. Lawson, Jayashri Kidao, John McCracken, C. Gregory Albers, Dennis J. Ahnen, D. Kim Turgeon, Steven Goldschmid, Peter Lance, Curt H. Hagedorn, Daniel L. Gillen, and Eugene W. Gerner
Cancer Prevention Research 2008 0: 194062070. [Abstract]