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Cancer Prevention Research 2, 843, October 1, 2009. Published Online First September 29, 2009;
doi: 10.1158/1940-6207.CAPR-09-0167
© 2009 American Association for Cancer Research
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Right arrowKey Article

Perspectives

Isolating the Effects of Social Interactions on Cancer Biology

Brian C. Trainor1,4, Colleen Sweeney4 and Robert Cardiff2,3

Authors' Affiliations: Departments of 1 Psychology and 2 Pathology, 3 Center for Comparative Medicine, University of California Davis, Davis, California; and 4 University of California Davis Cancer Center, Sacramento, California

Requests for reprints: Robert Cardiff, Department of Pathology and Laboratory Medicine, School of Medicine, 2795 Second Street, University of California Davis, Davis, CA 95616. Phone: 530-757-3279; Fax: 530-757-3277; E-mail: rdcardiff{at}ucdavis.edu.

This perspective on Williams et al. (beginning on p. 850 in this issue of the journal) examines the connections between biological responses activated during psychosocial stress and mammary tumorigenesis. Experiments in mouse models of cancer are identifying aspects of tumor biology that may be regulated by hormones such as glucocorticoids released during psychosocial stress. Our growing understanding of the actions of glucocorticoids on breast tumors could lead to important changes in cancer treatment.


Key Article

A Model of Gene-Environment Interaction Reveals Altered Mammary Gland Gene Expression and Increased Tumor Growth following Social Isolation
J. Bradley Williams, Diana Pang, Bertha Delgado, Masha Kocherginsky, Maria Tretiakova, Thomas Krausz, Deng Pan, Jane He, Martha K. McClintock, and Suzanne D. Conzen
Cancer Prevention Research 2009 2: 850-861. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2009 by the American Association for Cancer Research.