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Cancer Prevention Research 2, 847, October 1, 2009. Published Online First September 29, 2009;
doi: 10.1158/1940-6207.CAPR-09-0178
© 2009 American Association for Cancer Research
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Right arrowKey Article

Perspectives

Favoritism in DNA Methylation

Megan P. Hitchins and Robyn L. Ward

Authors' Affiliation: Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Kensington, New South Wales, Australia

Requests for reprints: Robyn Ward, Level 1, EBB POW Hospital, High Street, Randwick, 2031, Sydney, Australia. Phone: 61-2-9382-8870; Fax: 61-2-9382-8885; E-mail: robyn{at}unsw.edu.au.

This perspective on Candiloro and Dobrovic (beginning on p. 862 in this issue of the journal) highlights the interplay between epigenetic aberrations and underlying DNA sequence changes and illustrates how these alterations may predispose individuals to cancer. Candiloro and Dobrovic clearly show that particular genotypes of the MGMT gene are associated with its methylation in healthy individuals. Aberrant MGMT methylation may identify individuals who could be targeted for cancer screening and chemoprevention strategies.


Key Article

Detection of MGMT Promoter Methylation in Normal Individuals Is Strongly Associated with the T Allele of the rs16906252 MGMT Promoter Single Nucleotide Polymorphism
Ida L.M. Candiloro and Alexander Dobrovic
Cancer Prevention Research 2009 2: 862-867. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
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Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2009 by the American Association for Cancer Research.