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Cancer Prevention Research 2, 915, November 1, 2009. Published Online First October 27, 2009;
doi: 10.1158/1940-6207.CAPR-09-0208
© 2009 American Association for Cancer Research
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Perspectives

A Novel Look into Estrogen Receptor–Negative Breast Cancer Prevention with the Natural, Multifunctional Signal Transduction Inhibitor Deguelin

Jennifer M. Rodenberg and Powel H. Brown

Authors' Affiliation: Breast Center, Baylor College of Medicine, Houston, Texas

Requests for reprints: Powel H. Brown, Breast Center, Baylor College of Medicine, One Baylor Plaza, MS600, Houston, TX 77030. Phone: 713-798-1611; Fax: 713-798-1642; E-mail: pbrown{at}bcm.tmc.edu.

This perspective on Murillo et al. (beginning on page 942 in this issue of the journal) examines the potential of the naturally derived agent deguelin to prevent mammary tumorigenesis. These investigators showed that deguelin inhibits wnt/β-catenin signaling in breast cancer cell lines, in addition to inhibiting other previously reported signaling pathways. Our growing understanding of deguelin mechanisms could lead to important advances in the prevention of estrogen receptor–negative breast and other cancers.


Key Article

Deguelin Inhibits Growth of Breast Cancer Cells by Modulating the Expression of Key Members of the Wnt Signaling Pathway
Genoveva Murillo, Xinjian Peng, Karen E.O. Torres, and Rajendra G. Mehta
Cancer Prevention Research 2009 2: 942-950. [Abstract] [Full Text] [PDF]





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 2009 by the American Association for Cancer Research.