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Research Article

A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps

Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Arthur Shulkes, Elizabeth Cohen-Jonathan-Moyal, Audrey Ferrand and Catherine Seva
Catherine Do
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Claudine Bertrand
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Julien Palasse
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Marie-Bernadette Delisle
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Arthur Shulkes
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Elizabeth Cohen-Jonathan-Moyal
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Audrey Ferrand
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Catherine Seva
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DOI: 10.1158/1940-6207.CAPR-11-0408 Published April 2012
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Abstract

The most frequently occurring lesions in the colon are the hyperplastic polyps. Hyperplastic polyps have long been considered as lesions with no malignant potential and colonoscopy for these patients is not recommended. However, recent works suggest that hyperplastic polyps may represent precursor lesions of some sporadic colorectal cancers. Until now, no biomarker allows to identify the subset of hyperplastic polyps that may have a malignant potential. Because the hormone precursor progastrin has been involved in colon carcinogenesis, we investigated whether its expression in hyperplastic polyps predicts the occurrence of colonic neoplasm after resection of hyperplastic polyps. We retrospectively analyzed progastrin expression in hyperplastic polyps from 74 patients without history of colorectal pathology. In our study, 41% of patients presenting an initial hyperplastic polyp subsequently developed adenomatous polyps, recognized as precursor lesions for colorectal adenocarcinomas. Progastrin was overexpressed in the hyperplastic polyps in 40% of the patients. We showed a significant association between progastrin overexpression and shortened neoplasm-free survival (P = 0.001). Patients with high overexpression of progastrin had a 5-year neoplasm-free survival rate of 38% as compared with 100% for the patients with low progastrin expression. In addition, we established a predictive test on the basis of progastrin staining and patients' age that predicts occurrence of neoplasm after developing a first hyperplastic polyp with a sensitivity of 100% [95% confidence interval (CI), 79%–100%] and a specificity of 74% (51%–90%). We show that progastrin expression evaluation in hyperplastic polyps is an efficient prognostic tool to determine patients with higher risk of metachronous neoplasms who could benefit from an adapted follow-up. Cancer Prev Res; 5(4); 675–84. ©2012 AACR.

  • Received August 24, 2011.
  • Revision received January 12, 2012.
  • Accepted January 25, 2012.
  • ©2012 American Association for Cancer Research.
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Cancer Prevention Research: 5 (4)
April 2012
Volume 5, Issue 4
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A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps
Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Arthur Shulkes, Elizabeth Cohen-Jonathan-Moyal, Audrey Ferrand and Catherine Seva
Cancer Prev Res April 1 2012 (5) (4) 675-684; DOI: 10.1158/1940-6207.CAPR-11-0408

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A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps
Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Arthur Shulkes, Elizabeth Cohen-Jonathan-Moyal, Audrey Ferrand and Catherine Seva
Cancer Prev Res April 1 2012 (5) (4) 675-684; DOI: 10.1158/1940-6207.CAPR-11-0408
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Cancer Prevention Research
eISSN: 1940-6215
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