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Letter to the Editor

Dietary Omega-6 and Omega-3 Fatty Acids and Prostate Cancer – Letter

Maria Azrad and Wendy Demark-Wahnefried
Maria Azrad
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Wendy Demark-Wahnefried
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DOI: 10.1158/1940-6207.CAPR-12-0032 Published May 2012
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Recently, Aronson and colleagues (1) reported that men with prostate cancer receiving approximately 5 g/d of fish oil combined with a low-fat diet (15% kcal from fat) for 4 to 6 weeks before prostatectomy had 32% lower tumor ki67 staining compared with men consuming a Western diet (45% kcal from fat). This study is of interest because the data suggest that dietary modification can greatly reduce tumor proliferation rates. This article also included results of an in vitro bioassay where sera from subjects pre- and postintervention was used to culture 22RV1 prostate cancer cells and confirmed these findings. This in vitro bioassay has been reported previously by Aronson and colleagues (2, 3) as well as others (4) to provide evidence of chemoprevention. The in vitro bioassay is attractive, given its simplicity and potential for testing how in vivo changes associated with interventions affect cancer cell proliferation. However, to our knowledge, no study has reported the correlations between data from the in vitro bioassay and in vivo cell proliferation from the same individuals. This study provides a platform and opportunity to test the correlation between these 2 assays and determine whether the in vitro bioassay provides a similar depiction of the in vivo environment. Such data would serve as a substantive contribution to the literature, and we hope that the authors will consider publishing such findings.

See the Response, p. 799

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

  • Received January 24, 2012.
  • Accepted February 27, 2012.
  • ©2012 American Association for Cancer Research.

References

  1. 1.↵
    1. Aronson WJ,
    2. Kobayashi N,
    3. Barnard RJ,
    4. Henning S,
    5. Huang M,
    6. Jardack PM,
    7. et al.
    Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res 2011;4:2062–71.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    1. Aronson WJ,
    2. Barnard RJ,
    3. Freedland SJ,
    4. Henning S,
    5. Elashoff D,
    6. Jardack PM,
    7. et al.
    Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. J Urol 2010;183:345–50.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Soliman S,
    2. Aronson WJ,
    3. Barnard RJ
    . Analyzing serum-stimulated prostate cancer cell lines after low-fat, high-fiber diet and exercise intervention. Evid Based Complement Alternat Med 2009 Apr 17. [Epub ahead of print].
  4. 4.↵
    1. Azrad M,
    2. Chang PL,
    3. Gower BA,
    4. Hunter GR,
    5. Nagy TR
    . Reduced mitogenicity of sera following weight loss in premenopausal women. Nutr Cancer 2011;63:916–23.
    OpenUrlCrossRefPubMed
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Cancer Prevention Research: 5 (5)
May 2012
Volume 5, Issue 5
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Dietary Omega-6 and Omega-3 Fatty Acids and Prostate Cancer – Letter
Maria Azrad and Wendy Demark-Wahnefried
Cancer Prev Res May 1 2012 (5) (5) 798; DOI: 10.1158/1940-6207.CAPR-12-0032

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Dietary Omega-6 and Omega-3 Fatty Acids and Prostate Cancer – Letter
Maria Azrad and Wendy Demark-Wahnefried
Cancer Prev Res May 1 2012 (5) (5) 798; DOI: 10.1158/1940-6207.CAPR-12-0032
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Cancer Prevention Research
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