In this issue of the journal (beginning on page 1081), Zhang and colleagues extend the 30-year-old discovery of LOH profiles to provide validated markers of oral premalignant lesion risk for cancer. They prospectively show a dramatic difference in cancer progression between high-risk lesions (LOH) and low-risk (non-LOH) lesions (P = 0.002). This work has important implications for oral cancer prevention and risk modeling and for understanding genetic driver events in premalignancy. Cancer Prev Res; 5(9); 1–4. ©2012 AACR.
- Received May 14, 2012.
- Accepted June 5, 2012.
- ©2012 American Association for Cancer Research.