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Research Article

Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls

Kathryn L. Terry, Stalo Karageorgi, Yurii B. Shvetsov, Melissa A. Merritt, Galina Lurie, Pamela Thompson, Michael E. Carney, Rachel P. Weber, Lucy Akushevich, Wei-Hsuan Lo-Ciganic, Kara L. Cushing-Haugen, Weiva Sieh, Kirsten B. Moysich, Jennifer A. Doherty, Christina M. Nagle, Andrew Berchuck, Celeste Leigh Pearce, Malcolm Pike, Roberta B. Ness, Penelope Webb, Mary Anne Rossing, Joellen Schildkraut, Harvey A. Risch and Marc T. Goodman
Kathryn L. Terry
Obstetrics and Gynecology, Brigham and Womens Hospital
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  • For correspondence: kterry@partners.org
Stalo Karageorgi
Channing Lab, Brigham and Women's Hospital
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Yurii B. Shvetsov
Epidemiology Program, University of Hawaii Cancer Center
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Melissa A. Merritt
Department of Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital
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Galina Lurie
Cancer Epidemiology Program, University of Hawaii Cancer Center
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Pamela Thompson
Epidemiology, Samuel Oschin Comprehensive Cancer Institute
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Michael E. Carney
Obstetrics and Gynecology, University of Hawaii, John A. Burns School of Medicine
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Rachel P. Weber
Community & Family Medicine, Duke University
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Lucy Akushevich
Duke Institute for Genome Sciences and Policy, Duke Cancer Institute
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Wei-Hsuan Lo-Ciganic
University of Pittsburgh
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Kara L. Cushing-Haugen
Epidemiology, Fred Hutchinson Cancer Research Center
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Weiva Sieh
Health Research and Policy, Stanford University School of Medicine
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Kirsten B. Moysich
Department of Epidemiology, Roswell Park Cancer Institute
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Jennifer A. Doherty
Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth
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Christina M. Nagle
School of Public Health, Queensland Institute of Medical Research
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Andrew Berchuck
Dept of Obstetrics/Gynecology, Div of Gynecology/Oncology, Duke University Medical Center
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Celeste Leigh Pearce
Preventive Medicine, University of Southern California
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Malcolm Pike
Preventive Medicine, University of Southern California
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Roberta B. Ness
The University of Texas School of Public Health
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Penelope Webb
Public Health, Queensland Institute of Medical Research
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Mary Anne Rossing
Epidemiology, FHCRC Public Health
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Joellen Schildkraut
Epidemiology, Duke University
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Harvey A. Risch
Dept of Chronic Disease Epidemiology, Yale University School of Public Health
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Marc T. Goodman
Samuel Oschin Comprehensive Cancer Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center
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DOI: 10.1158/1940-6207.CAPR-13-0037
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Abstract

Genital powder use has been associated with risk of epithelial ovarian cancer in some, but not all, epidemiologic investigations, possibly reflecting the carcinogenic effects of talc particles found in most of these products. Whether risk increases with number of genital-powder applications and for all histologic types of ovarian cancer also remains uncertain. Therefore, we estimated the association between self-reported genital powder use and epithelial ovarian cancer risk in eight population-based case-control studies. Individual data from each study was collected and harmonized. Lifetime number of genital-powder applications was estimated from duration and frequency of use. Pooled odds ratios were calculated using conditional logistic regression matched on study and age and adjusted for potential confounders. Subtype-specific risks were estimated according to tumor behavior and histology. 8,525 cases and 9,859 controls were included in the analyses. Genital powder use was associated with a modest increased risk of epithelial ovarian cancer (odds ratio 1.24, 95% confidence interval 1.15-1.33) relative to women who never used powder. Risk was elevated for invasive serous (1.20, 1.09-1.32), endometrioid (1.22, 1.04-1.43), and clear cell (1.24, 1.01-1.52) tumors, and for borderline serous tumors (1.46, 1.24-1.72). Among genital powder users, we observed no significant trend (p=0.17) in risk with increasing number of lifetime applications (assessed in quartiles). We noted no increase in risk among women who only reported non-genital powder use. In summary, genital powder use is a modifiable exposure associated with small-to-moderate increases in risk of most histologic subtypes of epithelial ovarian cancer.

  • Received February 5, 2013.
  • Revision received April 23, 2013.
  • Accepted May 21, 2013.
  • Copyright © 2013, American Association for Cancer Research.
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Published OnlineFirst June 12, 2013
doi: 10.1158/1940-6207.CAPR-13-0037

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Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls
Kathryn L. Terry, Stalo Karageorgi, Yurii B. Shvetsov, Melissa A. Merritt, Galina Lurie, Pamela Thompson, Michael E. Carney, Rachel P. Weber, Lucy Akushevich, Wei-Hsuan Lo-Ciganic, Kara L. Cushing-Haugen, Weiva Sieh, Kirsten B. Moysich, Jennifer A. Doherty, Christina M. Nagle, Andrew Berchuck, Celeste Leigh Pearce, Malcolm Pike, Roberta B. Ness, Penelope Webb, Mary Anne Rossing, Joellen Schildkraut, Harvey A. Risch and Marc T. Goodman
Cancer Prev Res June 12 2013 DOI: 10.1158/1940-6207.CAPR-13-0037

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Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls
Kathryn L. Terry, Stalo Karageorgi, Yurii B. Shvetsov, Melissa A. Merritt, Galina Lurie, Pamela Thompson, Michael E. Carney, Rachel P. Weber, Lucy Akushevich, Wei-Hsuan Lo-Ciganic, Kara L. Cushing-Haugen, Weiva Sieh, Kirsten B. Moysich, Jennifer A. Doherty, Christina M. Nagle, Andrew Berchuck, Celeste Leigh Pearce, Malcolm Pike, Roberta B. Ness, Penelope Webb, Mary Anne Rossing, Joellen Schildkraut, Harvey A. Risch and Marc T. Goodman
Cancer Prev Res June 12 2013 DOI: 10.1158/1940-6207.CAPR-13-0037
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