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Commentary

Marshalling the translational potential of MC1R for precision risk assessment of melanoma

Peter A. Kanetsky and Jennifer L Hay
Peter A. Kanetsky
Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute
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  • For correspondence: peter.kanetsky@moffitt.org
Jennifer L Hay
Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center
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DOI: 10.1158/1940-6207.CAPR-17-0255
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Abstract

Melanoma rates have been increasing in the United States, and neither primary (sun protection and avoidance) nor secondary (skin examination) prevention is practiced consistently, even by those with melanoma risk factors. Inherited variation at MC1R is a robust marker for increased risk of melanoma, even among individuals with "sun-resistant" phenotypes. Although MC1R conveys important information about inherited melanoma risk for a broad spectrum of individuals, concerns that MC1R feedback could have negative consequences, including increased distress about melanoma, inappropriate use of health services, and development of a false sense of security are valid and require empirical examination. The time is right for high quality research focusing on the translation of MC1R genotype into clinical and public health practice. If studies show MC1R genetic risk screening is effective at motivating behavior change, more melanomas may be detected at earliest stages for which surgical excision is highly curative or a large number of melanomas may be prevented altogether. While other genetic markers for melanoma susceptibility may emerge in the coming years, the burgeoning research agenda on the public health translational potential of MC1R genetic risk screening will inform and usefully advance current and future precision risk assessment of melanoma.

  • Received August 13, 2017.
  • Revision received October 30, 2017.
  • Accepted December 7, 2017.
  • Copyright ©2017, American Association for Cancer Research.
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Published OnlineFirst December 15, 2017
doi: 10.1158/1940-6207.CAPR-17-0255

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Marshalling the translational potential of MC1R for precision risk assessment of melanoma
Peter A. Kanetsky and Jennifer L Hay
Cancer Prev Res December 15 2017 DOI: 10.1158/1940-6207.CAPR-17-0255

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Marshalling the translational potential of MC1R for precision risk assessment of melanoma
Peter A. Kanetsky and Jennifer L Hay
Cancer Prev Res December 15 2017 DOI: 10.1158/1940-6207.CAPR-17-0255
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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