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Review Article

PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal Cancer

Fernanda De Souza-Teixeira, Jéssica Alonso-Molero, Carlos Ayán, Laura Vilorio-Marques, Antonio J Molina, Carmen González-Donquiles, Veronica Davila-Batista, Tania Fernández-Villa, Jose Antonio de Paz and Vicente Martín
Fernanda De Souza-Teixeira
Gymnastic and Health, Exercise and Neuromuscular System Research Group, Superior School of Physical Education, Federal University of Pelotas, Brazil
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  • For correspondence: fteixeira13@hotmail.com
Jéssica Alonso-Molero
Medicina Preventiva y Salud Pública., Grupo de Investigación en Interacciones Gen-Ambiente y Salud
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Carlos Ayán
Special Didactics, Faculty of Education and Sport Science, University of Vigo, Spain
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Laura Vilorio-Marques
The Research Group of Gene-Environment and Health Interactions, University of León, Spain
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Antonio J Molina
Área de Medicina Preventiva y Salud Pública. Dpto. Ciencias Biomédicas, Grupo GIIGAS : Grupo de Investigación en Interacción Gen-Ambiente-Salud. Universidad de León
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  • ORCID record for Antonio J Molina
Carmen González-Donquiles
Area de Medicina Preventiva y Salud Pública, CIBERESP and Universidad de Oviedo. Grupo de Investigación en Interacciones Gen-Ambiente y Salud de la Universidad de León. Instituto de Biomedicina de León (IBIOMED)
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Veronica Davila-Batista
Medicina Preventiva y Salud Publica, The Research Group in Gene-Environment and Health Interactions, Vegazana Campus, University of León
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Tania Fernández-Villa
Facultad de Ciencias de la Salud. Departamento de Ciencias Biomédicas. Área de Medicina Preventiva y Salud Pública. Campus de Vegazana s/n, Universidad de León - Grupo de Investigación en Interacciones Gen Ambiente y Salud (GIIGAS) / Instituto de Biomedicina (IBIOMED)
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Jose Antonio de Paz
Institute of Biomedicine (IBIOMED), University of León, Spain
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Vicente Martín
Ciencias Biomedicas, Instituto de Biomedicina (IBIOMED), Universidad de León.
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DOI: 10.1158/1940-6207.CAPR-17-0329
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Abstract

Colorectal cancer is a significant public health concern. As a multistage and multifactorial disease, environmental and genetic factors interact at each stage of the process, and an individual's lifestyle also plays a relevant role. We set out to review the scientific evidence to study the need to investigate the role of the peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) gene as a biomarker of the physical activity's (PA) effect on colorectal cancer. PA is a protective factor against colorectal cancer and usually increases the expression of PGC-1α. This gene has pleiotropic roles and is the main regulator of mitochondrial functions. The development of colorectal cancer has been associated with mitochondrial dysfunction; in addition, alterations in this organelle are associated with colorectal cancer risk factors, such as obesity, decreased muscle mass, and the aging process. These are impacted by PA acting, among other aspects, on insulin sensitivity and oxygen reactive species/redox balance. Therefore, this gene demands special attention in the understanding of its operation in the consensual protective effect of PA in colorectal cancer. A significant amount of indirect evidence points to PGC-1α as a potential biomarker in the PA-protective effect on colorectal cancer.

  • Received October 16, 2017.
  • Revision received February 8, 2018.
  • Accepted May 15, 2018.
  • Copyright ©2018, American Association for Cancer Research.

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Published OnlineFirst May 22, 2018
doi: 10.1158/1940-6207.CAPR-17-0329

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PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal Cancer
Fernanda De Souza-Teixeira, Jéssica Alonso-Molero, Carlos Ayán, Laura Vilorio-Marques, Antonio J Molina, Carmen González-Donquiles, Veronica Davila-Batista, Tania Fernández-Villa, Jose Antonio de Paz and Vicente Martín
Cancer Prev Res May 22 2018 DOI: 10.1158/1940-6207.CAPR-17-0329

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PGC-1α as a Biomarker of Physical Activity-Protective Effect on Colorectal Cancer
Fernanda De Souza-Teixeira, Jéssica Alonso-Molero, Carlos Ayán, Laura Vilorio-Marques, Antonio J Molina, Carmen González-Donquiles, Veronica Davila-Batista, Tania Fernández-Villa, Jose Antonio de Paz and Vicente Martín
Cancer Prev Res May 22 2018 DOI: 10.1158/1940-6207.CAPR-17-0329
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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