Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Research Article

Methylation and expression of non-clustered protocadherins encoding genes and risk of precancerous gastric lesions in a high-risk population

Si Wu, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Wei-Cheng You and Kai-Feng Pan
Si Wu
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yang Zhang
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lian Zhang
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jun-Ling Ma
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tong Zhou
Department of Cancer Epidemiology, Peking University Cancer Hospital, Beijing Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhe-Xuan Li
Department of Cancer Epidemiology, Peking University Cancer Hospital, Beijing Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wei-Dong Liu
Department of Medical Oncology, Healthy Bureau of Linqu County
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wen-Qing Li
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wei-Cheng You
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kai-Feng Pan
Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pankaifeng2002@yahoo.com
DOI: 10.1158/1940-6207.CAPR-18-0119
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Non-clustered protocadherins (PCDHs) family is a group of cell-cell adhesion molecules. We have found differentially methylated genes in the non-clustered PCDHs family associated with Helicobacter pylori (H. pylori) infection in prior genome-wide methylation analysis. To further investigate the methylation and expression of non-clustered PCDHs encoding genes in H. pylori-related gastric carcinogenesis process, four candidate genes including PCDH7, PCDH10, PCDH17 and PCDH20 were selected, which were reported to be tumor suppressors for digestive cancers. A total of 747 participants with a spectrum of gastric lesions were enrolled from a high-risk population of gastric cancer. Promoter methylation levels of four genes were significantly higher in H. pylori positive subjects than the negative group (all P<0.001). Elevated methylation levels of PCDH10 and PCDH17 were observed with the increasing severity of gastric lesions (both Ptrend<0.001). In the protein expression analysis, PCDH17 expression was inversely associated with gastric lesions; the OR (95% CI) was 0.49 (0.26-0.95) for chronic atrophic gastritis (CAG), 0.31 (0.15-0.63) for intestinal metaplasia, and 0.38 (0.19-0.75) for indefinite dysplasia and dysplasia, compared with superficial gastritis (SG). In addition, PCDH10 expression was significantly lower in CAG (OR=0.40, 95% CI=0.24-0.68). The inverse association between methylation and protein expression of PCDH10 and PCDH17 was further supported when we explored the methylation and mRNA expression in The Cancer Genome Atlas database (all P<0.001). Our study found elevated promoter methylation and decreased expression of PCDH10 and PCDH17 in advanced gastric lesions, suggesting that elevated PCDH10 and PCDH17 methylation may be an early event in gastric carcinogenesis.

  • Received April 9, 2018.
  • Revision received June 1, 2018.
  • Accepted August 29, 2018.
  • Copyright ©2018, American Association for Cancer Research.

Log in using your username and password

Forgot your user name or password?

Purchase Short Term Access

Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$35.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Next
Back to top

Published OnlineFirst September 13, 2018
doi: 10.1158/1940-6207.CAPR-18-0119

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Prevention Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Methylation and expression of non-clustered protocadherins encoding genes and risk of precancerous gastric lesions in a high-risk population
(Your Name) has forwarded a page to you from Cancer Prevention Research
(Your Name) thought you would be interested in this article in Cancer Prevention Research.
Citation Tools
Methylation and expression of non-clustered protocadherins encoding genes and risk of precancerous gastric lesions in a high-risk population
Si Wu, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Wei-Cheng You and Kai-Feng Pan
Cancer Prev Res September 13 2018 DOI: 10.1158/1940-6207.CAPR-18-0119

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Methylation and expression of non-clustered protocadherins encoding genes and risk of precancerous gastric lesions in a high-risk population
Si Wu, Yang Zhang, Lian Zhang, Jun-Ling Ma, Tong Zhou, Zhe-Xuan Li, Wei-Dong Liu, Wen-Qing Li, Wei-Cheng You and Kai-Feng Pan
Cancer Prev Res September 13 2018 DOI: 10.1158/1940-6207.CAPR-18-0119
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Role of KLF4 in bCSC Suppression by BITC
  • Cervical Screening by Self-collection, Pap, or a Choice
  • Colorectal Cancer Chemoprevention
Show more Research Article
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Prevention Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

Advertisement