Table 1.

Hallmarks of cancer phenotypes and their effects on the model when mutated

PhenotypeModel effect
Insensitivity to antigrowth signalsCells with this mutation have an increased probability for cell division
Self-sufficiency in growth signalsCells with this mutation have an increased probability for cell division
Evasion of apoptosisCells with this mutation have a decreased probability of apoptosis
Limitless replicative potentialMutation eliminates telomere loss during cell division. Cells with this mutation can divide more times than those without.
Sustained angiogenesisCells with this mutation increase the number of cells that can survive in a tumor.
Loss of differentiationCells with this mutation no longer differentiate at cell division.
Genome instabilityCells with this mutation have increased chances to acquire a new mutation.