Table 1.

Kappa statistic (κ) of interclassification agreement, 95% CIs, and agreement percentage between classification of samples by promoter methylation of EDNRB, HOXA9, GATA4, NID2, MCAM, KIF1A, DCC, CALCA, and by clinical diagnosis (discovery screen − n = 36) and by histology (prevalence screen − n = 92)

VariableKappa coefficient
κ (95% CI)Percentage agreement (%)
Discovery screen
 HOXA90.60 (0.36–0.84)79
 NID20.60 (0.36–0.84)80
 GATA40.37 (0.09–0.65)67
 KIF1A0.64 (0.39–0.89)82
 EDNRB0.60 (0.36–0.84)79
 DCC0.44 (0.18–0.70)71
 MCAM−0.12 (−0.42–0.18)41
 CALCA0.24 (−0.02–0.51)59
Prevalence screen
 HOXA90.82 (0.70–0.94)91
 NID20.80 (0.68–0.92)90