Table 3.

Comparison of specificity and sensitivity of the training, validation, and postvalidation sets

Study groupAntigens in panelNumber: Ca/N% NSCLCOverall sensitivity/specificity (%)Sensitivity NSCLCSensitivity SCLCSpecificity for lung cancer
Training setaOD6234/2257139/89364589
Validation setaRU6269/2697637/9034 (27, 41)45 (34, 57)90 (86, 93)
Group 1RU6122/0057/NA-57-
Group 2RU6249/4839734/8734N/D90
Group 3RU6122/11410031/843184
Group 4RU681/2056238/89354389
All studies61,077/1,30638/8834 (31, 38)50 (44, 56)88 (86, 90)
Validation + 1–46843/1,07138/8833 (30, 37)51 (44, 58)88 (86, 90)
Groups 1–46574/80239/8733 (29, 38)54 (46, 62)87 (85, 89)
Groups 2–46452/80234/8733 (29, 38)43 (25, 63)87 (85, 89)

Abbreviations: NA, not applicable; N/D, not analyzed; OD, optical density; RU, reference unit.

  • aPreviously published.