Table 4.

Health and economic outcomes of several primary genetic screening strategies with varying levels of adoption relative to current practice patterns

Screening strategyPercentage of population adopting primary genetic screening (%)Reduction of colorectal cancer incidence in carriers exposed to screening strategy (%)Reduction of endometrial cancer incidence in carriers exposed to screening strategy (%)Absolute life-years saved per carrier exposed to screening strategy (y)Average cost-effectiveness ratio ($/QALY)
StrategyScreening start-age (y)Risk threshold (%)
12255.0100%13.59.01.0927,571
67%9.16.00.7327,535
33%4.53.00.3627,580
13305.0100%13.08.71.0726,229
67%8.75.80.7126,351
33%4.32.90.3526,177
14355.0100%12.28.10.9924,585
67%8.25.40.6624,602
33%4.02.70.3324,511