Table 2.

Comparison of methylation values in all the BRCA1 methylated tumor DNAs with the corresponding peripheral blood DNA from group 1 and group 3 women

Tumor IDTumor content (%)MethyLight (%)MS-HRM (%)Corresponding peripheral blood DNA (%)
Tumor-enriched DNA samples from group 1 women
T1.192150100<1
T1.295203.31100<1
T1.395168.781001–5
T1.49095.23501–5
T1.58078.9350–100>5
T1.68072.7350Not methylated
T1.77056.51100Not methylated
T1.89044.45100<1
T1.99022.891001–5
Tumor-enriched DNA samples from group 3 women
T3.18036.0850Not methylated
T3.260150.1950–100Not methylated
T3.360Not methylated11–5

NOTE: Both MethyLight and MS-HRM methylation estimates are shown. Twenty tumors were available from group 1 women with 5 or more of 9 BRCA1 mutation-associated morphologic features and 32 tumors were available from group 3 women with 3 or less features. Only the methylated tumors are shown. Consensus methylation values for the corresponding peripheral blood DNA are shown. The complete data are shown in Supplementary Tables S5 and S6.