Table 4.

Phase III results (AUC and sensitivity at 95% specificity) by the 5 sites

SiteMarkerCVaCases diagnosed ≤6 mo after draw (n = 45)Cases diagnosed >6–12 mo after draw (n = 22)Cases diagnosed >12–18 mo after draw (n = 17)Cases diagnosed >18 mo after draw (n = 34)
AUCSensitivity (95% CI)AUCSensitivity (95% CI)AUCSensitivity (95% CI)AUCSensitivity (95% CI)
PLCOCA1250.960.86 (0.76, 0.97)0.750.33 (0.13, 0.53)0.720.12 (0.00, 0.27)0.540.03 (0.00, 0.09)
FHCRCCA1250.110.940.80 (0.68, 0.92)0.500.32 (0.12, 0.51)0.500.12 (0.00, 0.27)0.500.12 (0.01, 0.23)
HE40.190.810.60 (0.46, 0.74)0.660.23 (0.05, 0.40)0.550.06 (0.00, 0.17)0.600.09 (0.00, 0.18)
MMP70.090.650.20 (0.08, 0.32)0.500.14 (0.00, 0.28)0.620.18 (0.00, 0.36)0.480.12 (0.01, 0.23)
Mesothelin0.130.720.40 (0.26, 0.54)0.570.000.620.06 (0.00, 0.17)0.440.00
Spondin-20.180.610.11 (0.02, 0.20)0.540.14 (0.00, 0.28)0.580.06 (0.00, 0.17)0.570.12 (0.01, 0.23)
SLPI0.080.630.16 (0.05, 0.26)0.530.09 (0.00, 0.21)0.560.06 (0.00, 0.17)0.540.03 (0.00, 0.09)
IGFBP20.080.640.09 (0.01, 0.17)0.600.000.490.000.560.03 (0.00, 0.09)
MDACCB2M0.170.560.09 (0.01, 0.17)0.630.05 (0.00, 0.13)0.600.000.540.15 (0.03, 0.27)
Transferrin0.120.540.09 (0.01, 0.17)0.530.09 (0.00, 0.21)0.580.000.530.00
CTAP-III0.140.570.09 (0.01, 0.17)0.560.05 (0.00, 0.13)0.510.12 (0.00, 0.27)0.500.09 (0.00, 0.18)
Hepcidin0.150.530.09 (0.01, 0.17)0.580.05 (0.00, 0.13)0.540.12 (0.00, 0.27)0.510.00
Transthyretin0.120.570.02 (0.00, 0.07)0.550.05 (0.00, 0.13)0.550.12 (0.00, 0.27)0.500.09 (0.00, 0.18)
ITIH40.260.510.04 (0.00, 0.10)0.510.05 (0.00, 0.13)0.590.000.520.03 (0.00, 0.09)
Apolipoprotein A10.170.490.07 (0.00, 0.14)0.550.05 (0.00, 0.13)0.510.12 (0.00, 0.27)0.540.00
PartnersCA1250.040.960.86 (0.76, 0.97)0.770.36 (0.16, 0.56)0.640.06 (0.00, 0.18)0.530.03 (0.00, 0.09)
HE40.080.880.73 (0.60, 0.86)0.650.23 (0.05, 0.40)0.700.18 (0.00, 0.36)0.660.12 (0.01, 0.23)
CA72.40.040.800.44 (0.29, 0.59)0.590.14 (0.00, 0.28)0.500.20 (0.00, 0.40)0.540.06 (0.00, 0.14)
B7-H40.250.700.36 (0.22, 0.50)0.560.05 (0.00, 0.13)0.500.000.470.09 (0.00, 0.18)
CA15.30.020.720.45 (0.31, 0.60)0.540.05 (0.00, 0.13)0.650.27 (0.04, 0.49)0.520.03 (0.00, 0.09)
KLK60.140.730.32 (0.18, 0.46)0.570.05 (0.00, 0.13)0.590.07 (0.00, 0.19)0.570.06 (0.00, 0.14)
CA19.90.020.500.14 (0.03, 0.24)0.490.000.660.19 (0.00, 0.38)0.520.09 (0.00, 0.18)
UPCICA1250.160.830.27 (0.14, 0.40)0.390.000.560.000.500.06 (0.00, 0.14)
HE40.180.780.31 (0.18, 0.45)0.470.09 (0.00, 0.21)0.540.000.570.09 (0.00, 0.18)
Eotaxin0.080.560.02 (0.00, 0.07)0.600.09 (0.00, 0.21)0.530.06 (0.00, 0.17)0.510.09 (0.00, 0.18)
MMP30.090.560.02 (0.00, 0.07)0.530.05 (0.00, 0.14)0.500.000.500.15 (0.03, 0.27)
CA72.40.130.440.02 (0.00, 0.07)0.460.000.630.000.510.09 (0.00, 0.18)
sV-CAM0.110.570.04 (0.00, 0.10)0.540.000.570.12 (0.00, 0.27)0.500.15 (0.03, 0.27)
EGFR0.060.520.04 (0.00, 0.10)0.540.09 (0.00, 0.21)0.590.06 (0.00, 0.17)0.520.06 (0.00, 0.14)
Prolactin0.120.540.13 (0.03, 0.23)0.660.09 (0.00, 0.21)0.480.12 (0.00, 0.27)0.500.03 (0.00, 0.09)
YUSMCA1250.290.960.84 (0.74, 0.95)0.720.23 (0.05, 0.40)0.580.12 (0.00, 0.27)0.540.06 (0.00, 0.14)
MIF0.580.650.18 (0.07, 0.29)0.480.09 (0.00, 0.21)0.560.000.570.18 (0.05, 0.30)
Leptin0.090.520.04 (0.00, 0.10)0.510.05 (0.00, 0.13)0.530.12 (0.00, 0.27)0.540.06 (0.00, 0.14)
Prolactin0.130.550.09 (0.01, 0.17)0.680.09 (0.00, 0.21)0.500.06 (0.00, 0.17)0.560.06 (0.00, 0.14)
OPN0.540.590.11 (0.02, 0.20)0.560.05 (0.00, 0.13)0.550.06 (0.00, 0.17)0.540.06 (0.00, 0.14)
IGF20.310.600.04 (0.00, 0.10)0.460.05 (0.00, 0.13)0.460.06 (0.00, 0.17)0.490.03 (0.00, 0.09)
  • aCV were calculated for each of the 60 QC duplicate pairs inserted in the allocated samples and were then averaged over all pairs to obtain the average CV for the assay.