Table 1.

CV based on 84 replicates and Pearson correlations (r) based on 40 paired serial samples for assays in the common phase II set by site

Marker NamePartnersFHCRCMDACCUPCI
AFP0.15 (0.92)
Apolipoprotein A10.23 (0.39)
B7-H40.29 (0.63)
B2M0.10 (0.64)
CA1250.10 (0.94)0.12 (0.92)0.61 (0.80)
CA15.30.12 (0.89)0.26 (0.89)
CA19.90.09 (0.89)0.30 (0.70)
CA72.40.19 (0.69)0.14 (0.88)
CEA0.11 (0.83)
Chitinase0.17 (0.44)
CTAP-III0.12 (0.62)
Cytokeratin 190.33 (0.01)
DcR30.06 (0.64)
EGFR0.13 (0.83)
Eotaxin0.52 (0.34)
ErbB20.14 (0.76)
Follicle stimulating hormone0.18 (0.81)
GH0.29 (0.17)
HE40.06 (0.74)0.25 (0.78)0.23 (0.87)
Hepcidin0.18 (0.56)
IGF20.07 (0.72)
IGFBP10.25 (0.61)
IGFBP20.16 (0.82)
Interleukin 100.27 (0.64)
Interleukin 2 receptor0.28 (0.55)
Interleukin 60.28 (0.72)
Interleukin 6 receptor0.15 (0.84)
Interleukin 80.32 (0.52)
ITIH40.21 (0.59)
KLK60.21 (0.32)
KLK80.32 (0.52)
Luteinizing hormone0.19 (0.84)
MIF0.41 (0.52)
MIC10.41 (0.83)
Mesothelin0.42 (0.72)0.16 (0.75)0.18 (0.88)
MMP20.14 (0.42)
MMP30.15 (0.74)
MMP90.19 (0.33)
MPO0.44 (0.23)
Prolactin0.24 (0.01)
Soluble intracellular adhesion molecule 10.31 (0.43)
sV-CAM0.25 (0.54)
Spondin-20.13 (0.64)0.17 (0.63)
TNFα0.27 (0.38)
TNFr20.50 (0.28)
Total plasminogen activator inhibitor0.32 (0.54)
Transthyretin0.18 (0.39)
Transferrin0.17 (0.38)
TSH0.21 (0.77)

NOTE: All values are given as CV (r). Partners performed platform (Roche E170) or plate-based assays; FHCRC performed singleplex Luminex bead assays and plate-based assays; MDACC performed a mass spectrographic analysis using surface-enhanced antibody chips; UPCI performed multiplexed Luminex bead assays.

Abbreviations: B2M, β-2 microglobulin; CTAP-III, connective tissue activating protein III; ITIH4, inter-α-trypsin inhibitor heavy chain; TSH, thyroid stimulating hormone