Table 3.

Gender-dependent differences in the effect of smoking on the expression of select genes in the oral mucosa

Gene nameAffymetrix IDFemale foldMale foldInteraction PGene title
AKR1C3209160_at1.61.10.0196Aldo-keto reductase family 1, member C3 (3α-hydroxysteroid dehydrogenase, type II)
AKR1C2209699_x_at1.51.10.0266Aldo-keto reductase family 1, member C2
UGT1A1 // UGT1A3 to UGT1A10206094_x_at1.71.30.0313UDP glucuronosyltransferase 1 family, polypeptide A1, A3 to A10
UGT1A1 // UGT1A4 // UGT1A6 // UGT1A8 to UGT1A10204532_x_at1.81.30.0346UDP glucuronosyltransferase 1 family, polypeptide A1, A4, A6, A8 to A10
UGT1A1 // UGT1A4 // UGT1A6 // UGT1A8 to UGT1A10207126_x_at1.81.30.0423UDP glucuronosyltransferase 1 family, polypeptide A1, A4, A6, A8 to A10
IGFL1239430_at−2.1−1.00.0210Insulin-like growth factor-like family member 1

NOTE: Differentially expressed genes (fold changes) in the oral mucosa of smokers versus never smokers for females and males, respectively. Interaction P values indicate that the magnitude of the change in gene expression induced by smoking was greater in females than males for each of the genes shown below (annotations from November 2008 NetAffx).