Table 4.

Genes that are overexpressed in the oral mucosa of smokers are also commonly overexpressed in the airways of smokers

Oral versus airway
Gene nameAffymetrix IDOral mucosa fold (P)Airway fold (P)Gene title
CYP1B1202437_s_at4.2 (1.1E−11)8.1 (1.2E−07)Cytochrome P450, family 1, subfamily B, polypeptide 1
CYP1B1202436_s_at3.2 (5.5E−10)7.1 (2.4E−07)Cytochrome P450, family 1, subfamily B, polypeptide 1
CYP1A1205749_at2.5 (3.1E−05)2.8 (5.6E−04)Cytochrome P450, family 1, subfamily A, polypeptide 1
GPX2202831_at2.1 (3.1E−04)3.3 (5.8E−14)Glutathione peroxidase 2 (gastrointestinal)
NQO1201468_s_at1.7 (6.9E−04)3.7 (4.1E−13)NAD(P)H dehydrogenase, quinone 1
NQO1210519_s_at1.6 (1.9E−03)3.6 (4.5E−14)NAD(P)H dehydrogenase, quinone 1
NQO1201467_s_at1.5 (4.4E−03)3.2 (6.7E−12)NAD(P)H dehydrogenase, quinone 1
ALDH3A1205623_at1.6 (7.5E−04)6.5 (3.4E−12)Aldehyde dehydrogenase 3 family, member A1
UGT1A1 /// UGT1A3 to UGT1A10215125_s_at1.5 (2.1E−03)2.2 (1.4E−08)UDP glucuronosyltransferase 1 family, polypeptide A1 /// A3 to A10
UGT1A1 /// UGT1A4 /// UGT1A6 /// UGT1A8 to UGT1A10207126_x_at1.5 (3.1E−04)1.8 (2.0E−08)UDP glucuronosyltransferase 1 family, polypeptide A1 /// A4 /// A6 /// A8 to A10
MUC1207847_s_at(>0.05)1.6 (0.021)Mucin 1, cell surface associated
MUC1213693_s_at1.5 (0.043)1.4 (0.015)Mucin 1, cell surface associated
CEACAM5201884_at1.3 (0.011)5.4 (3.8E−11)Carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6203757_s_at(>0.05)2.4 (1.3E−4)Carcinoembryonic antigen-related cell adhesion molecule 6
CEACAM6211657_at(>0.05)2.3 (2.1E−4)Carcinoembryonic antigen-related cell adhesion molecule 6
CEACAM7206198_s_at3.0 (0.031)(>0.05)Carcinoembryonic antigen-related cell adhesion molecule 7
FCGBP203240_at2.0 (3.1E−05)−2.3 (0.01)Fc fragment of IgG binding protein

NOTE: Differentially expressed genes (fold changes) in the oral and airway mucosa of smokers versus never smokers with associated P values (ANOVA). The CEACAM family genes CEACAM5 and CEACAM6 are induced in the airways of smokers, whereas CEACAM7 is induced in the oral mucosa of smokers. FCGBP is induced in the oral mucosa but repressed in the airway of smokers.