Table 3.

Phase II results for all cases and early-stage cases compared with general population controls by sensitivity at 95% specificity and AUC (sorted by sensitivity for all cases)

All cases and general population controlsEarly-stage cases and general population controls
Sensitivity (95% CI)RankAUC (95% CI)RankSensitivity (95% CI)RankAUC (95% CI)Rank
CA1250.73 (0.64–0.84)10.92 (0.89–0.95)10.56 (0.49–0.72)10.89 (0.85–0.93)1
HE40.57 (0.50–0.70)20.86 (0.83–0.89)20.29 (0.19–0.45)50.75 (0.70–0.82)2
Transthyretin0.47 (0.38–0.56)30.80 (0.75–0.84)30.29 (0.21–0.37)40.71 (0.64–0.78)4
CA15.30.46 (0.39–0.54)40.74 (0.69–0.78)90.33 (0.23–0.44)20.63 (0.57–0.70)15
CA72.40.40 (0.33–0.52)50.75 (0.71–0.80)70.20 (0.12–0.31)90.63 (0.57–0.69)17
IGFBP20.38 (0.30–0.45)60.74 (0.69–0.79)100.20 (0.11–0.29)110.63 (0.57–0.71)16
Cytokeratin 190.37 (0.25–0.45)70.74 (0.69–0.77)110.14 (0.03–0.22)220.61 (0.55–0.68)22
IGF20.36 (0.28–0.49)80.80 (0.76–0.83)40.15 (0.08–0.26)170.69 (0.63–0.76)7
KLK60.36 (0.26–0.43)90.71 (0.65–0.76)150.12 (0.04–0.20)290.59 (0.52–0.66)28
Mesothelin0.35 (0.27–0.46)100.71 (0.65–0.76)160.12 (0.06–0.22)270.60 (0.52–0.69)25
B7-H40.35 (0.27–0.42)110.67 (0.63–0.73)180.19 (0.10–0.28)130.59 (0.52–0.67)26
Apolipoprotein A10.34 (0.26–0.43)120.77 (0.73–0.80)60.28 (0.15–0.39)60.68 (0.62–0.74)8
sV-CAM0.34 (0.22–0.42)130.75 (0.71–0.79)80.27 (0.08–0.41)80.67 (0.60–0.74)9
Prolactin0.34 (0.15–0.49)140.77 (0.74–0.81)50.28 (0.12–0.41)70.69 (0.63–0.76)6
Chitinase0.31 (0.23–0.38)150.74 (0.69–0.80)120.13 (0.06–0.21)240.63 (0.57–0.69)18
Spondin-20.28 (0.18–0.36)160.74 (0.69–0.79)130.11 (0.03–0.18)310.62 (0.55–0.68)21
MIC10.24 (0.14–0.30)170.62 (0.57–0.67)270.16 (0.08–0.26)150.54 (0.50–0.62)39
CA19.90.23 (0.18–0.30)180.61 (0.57–0.66)280.31 (0.23–0.46)30.74 (0.69–0.80)3
Transferrin0.23 (0.15–0.32)190.71 (0.66–0.75)170.19 (0.08–0.30)140.65 (0.60–0.72)11
IGFBP10.21 (0.15–0.31)200.72 (0.68–0.76)140.11 (0.04–0.19)300.64 (0.57–0.70)12
Hepcidin0.21 (0.12–0.28)210.62 (0.57–0.67)260.12 (0.05–0.22)280.57 (0.51–0.65)30
TSH0.19 (0.13–0.25)220.60 (0.56–0.65)300.15 (0.07–0.21)190.54 (0.50–0.60)36
CTAP-III0.19 (0.12–0.24)230.51 (0.50–0.57)470.15 (0.08–0.24)180.51 (0.50–0.58)45
MMP30.17 (0.11–0.27)240.64 (0.59–0.67)240.14 (0.07–0.28)210.60 (0.53–0.67)24
MMP20.17 (0.08–0.28)250.64 (0.59–0.69)220.20 (0.08–0.32)120.62 (0.55–0.69)20
GH0.16 (0.10–0.23)260.67 (0.61–0.72)190.15 (0.06–0.26)200.63 (0.57–0.69)14
MIF0.15 (0.09–0.24)280.66 (0.62–0.71)200.16 (0.06–0.22)160.58 (0.53–0.64)29
Eotaxin0.15 (0.07–0.23)300.64 (0.59–0.69)230.10 (0.05–0.18)330.61 (0.54–0.67)23
MPO0.14 (0.09–0.22)310.55 (0.50–0.61)420.20 (0.11–0.30)100.70 (0.62–0.75)5
EGFR0.10 (0.05–0.17)350.64 (0.60–0.69)210.09 (0.02–0.21)340.59 (0.52–0.68)27
ITIH40.09 (0.05–0.16)370.57 (0.51–0.62)390.04 (0.00–0.10)480.51 (0.50–0.58)46
B2M0.05 (0.02–0.12)450.56 (0.51–0.61)410.05 (0.00–0.12)470.50 (0.50–0.58)49