Table 2.

Functional gene groups altered in the oral mucosa of smokers versus never smokers

Gene set
Pathways enriched in smokers (using GSEA version 2)FDR
Metabolism of xenobiotics by cytochrome P4500.01↑ (KEGG)
Androgen and estrogen metabolism0.110↑ (KEGG)
Eicosanoid synthesis0.075↑ (GenMAPP)
Prostaglandin and leukotriene metabolism0.128↑ (GenMAPP)
Glutathione metabolism0.166↑ (KEGG), 0.093↑ (GenMAPP)
GO groups enriched in smokers (using EASE)Bonferroni P
GO molecular function: electron transporter activity0.00085 (8/27)↑
GO molecular function: oxidoreductase activity0.049 (8/27)↑