Table 1.

Immunohistochemical expression of phosphorylated S6 ribosomal protein and serine-phosphorylated IRS-1 in normal proliferative endometrium, endometrial CAH, and EEC grade 1

GroupPhospho-(S235) S6, n (%)Phospho-(S636/639) IRS-1, n (%)
Normal (n = 6)1 (17)6 (100)
CAH (n = 25)24 (96)*5 (20)
EEC grade 1 (n = 10)9 (90)*2 (18)

NOTE: All of these tissues expressed IRS-1 and/or IRS-2. Results are expressed as the number of cases with 2+ or 3+ immunohistochemical expression. Correlation between expression of phospho-(S235) S6 and phospho-(S636/639) IRS-1 was determined by Pearson's correlation (P < 0.025).

  • *Statistically significant as compared with normal endometrium at the P < 0.001 level by χ2 analysis.