Table 4.

Treatment effects on free and bound GSH levels in the tumors and red blood cells

Experimental groupsRed blood cells (mmol/g of packed cells)*Tumors (mmol/g)
FreeBoundFreeBound
A5% CO, no MNU1.75 ± 0.160.32 ± 0.04
(3)(3)
B5% CO2.95 ± 0.460.47 ± 0.07
(10)(10)
C20% CO2.75 ± 0.640.48 ± 0.08
(11)(11)
D20% CO + 50 μg/kg tamoxifen2.93 ± 0.680.43 ± 0.0885.52 ± 107§12.8 ± 17.45
(12)(12)(15)(15)
E20% CO + 100 μg/kg tamoxifen2.87 ± 0.530.46 ± 0.07
(12)(12)
F17% FO2.94 ± 0.740.40 ± 0.09
(11)(11)
G17% FO + 50 μg/kg tamoxifen2.91 ± 0.590.37 ± 0.0633.56 ± 26.64.41 ± 7.28
(12)(12)(15)(15)
H17% FO + 100 μg/kg tamoxifen2.78 ± 0.410.39 ± 0.06
(8)(8)

NOTE: Red blood cells and tumor levels of free and bound GSH were measured in randomly selected rats from the indicated experimental groups plus in rats that were not injected with MNU. Data represent mean ± SE. Numbers in parentheses indicate the number of observations.

  • *Results were identical if data are expressed as mmol/g hemoglobin.

  • P = 0.001 versus the rest of the groups.

  • P = 0.02 versus the rest of the groups.

  • §P = 0.01 versus G.