Table 2.

Results of NBC sensor analysis of EGFR biomarker expression and cytomorphometry in oral lesions according to histopathologic diagnosis

Healthy (n = 11)Benign (n = 3)Dysplasia (n = 7)SCC (n = 31)
Nuclear area (μm2)63.4 ± 11122 ± 57*149 ± 23*165 ± 46*
P < 0.004P < 0.001P < 0.001
Nuclear diameter (μm)11.5 ± 0.7014.8 ± 3.2*16.1 ± 1.2*17.3 ± 2.6*
P < 0.005P < 0.001P < 0.001
Cellular area (μm2)1,040 ± 1601,300 ± 5001,040 ± 260697 ± 230*
P < 0.15P < 0.99P < 0.001
Cellular diameter (μm)51.5 ± 4.455.1 ± 1249.9 ± 6.341.1 ± 7.1*
P < 0.4P < 0.6P < 0.001
N/C ratio0.063 ± 0.020.206 ± 0.17*0.223 ± 0.10*0.323 ± 0.14*
P < 0.01P < 0.001P < 0.001
EGFR intensity (au)5.99 ± 1.47.10 ± 1.89.53 ± 4.3*11.8 ± 6.5*
P < 0.3P < 0.03P < 0.006

NOTE: Data are presented as mean ± SD.

  • *Statistically significant difference relative to healthy controls using paired t test (P < 0.05).