Table 1.

Influence of celecoxib, piroxicam, and zileuton on survival and oral cancer incidence in rats treated with NQO

GroupAgentAgent dose (mg/kg diet)Survival (%)Number (%) with lesion
Squamous epithelial hyperplasiaSquamous cell papillomaSquamous cell carcinoma
1None (control)15/30 (50)0/27 (0)0/27 (0)26/27 (96)
2Celecoxib50024/30 (80)*3/27 (11)1/27 (4)19/27 (70)*
3Celecoxib1,50027/30 (90)5/28 (18)*1/28 (4)21/28 (75)*
4Piroxicam5027/30 (90)4/28 (14)*0/28 (0)23/28 (82)
5Piroxicam15025/30 (83)5/29 (17)*0/29 (0)24/29 (83)
6Zileuton2,00015/30 (50)1/25 (4)0/25 (0)24/25 (96)
  • *P < 0.05 versus dietary control (group 1).

  • P < 0.01 versus dietary control group.

  • 0.05 < P < 0.10 versus dietary control group.