Table 1.

Serum concentration of sulindac and sulindac metabolites, overall and by dose

TreatmentBiomarker (μg/mL)MedianMean (± SD)P*
All (n = 30)Sulindac2.42.95 ± 1.99
Sulfide2.63.89 ± 3.55
Sulfone1.61.95 ± 1.42
150 mg q.d. (n = 15)Sulindac2.22.50 ± 1.93
Sulfide2.42.43 ± 1.79
Sulfone1.21.41 ± 0.95
150 mg b.i.d. (n = 15)Sulindac3.33.37 ± 2.020.275
Sulfide4.05.35 ± 4.280.059
Sulfone1.92.49 ± 1.620.048
  • *Two-sided Wilcoxon rank-sum test for difference between dose groups.