Table 2.

Folate concentrations in lymphocytes and tissues from rats fed a folate-supplemented (F+) or folate-deficient (F) diet for 24 wk

Folate (ng/mg protein)Depletion (%)
F+F
Lymphocyte (ng/105 cells)0.45 ± 0.08 (8)0.27 ± 0.03* (8)39
Liver136.2 ± 6.9 (10)93.9 ± 16.3* (10)31
Colon (ascending)25.7 ± 4.2 (10)11.9 ± 1.1 (10)54
Colon (transverse)27.4 ± 3.2 (9)10.5 ± 1.6 (10)62
Colon (descending)24.6 ± 1.9 (10)9.9 ± 1.8§ (10)60
Spleen16.5 ± 2.9 (10)7.9 ± 1.1 (10)52
Kidney58.6 ± 7.5 (10)26.6 ± 2.7 (10)55
Brain20.4 ± 0.5 (6)15.3 ± 2.2* (6)25
Heart9.2 ± 1.2 (10)3.4 ± 0.3 (10)63

NOTE: Values are the mean ± SE, with number of rats sampled per group in parentheses. Significance refers to differences between F+ versus F animals at the end of the experiment.

  • *P < 0.05.

  • P < 0.01.

  • P < 0.001.

  • §P < 0.0001.