Table 2.

Nipple aspirate concentration of sulindac and sulindac sulfide, overall and by dose

TreatmentBiomarker (ng/mL)MedianMean (± SD)P*
All (n = 26)Sulindac39.895.8 ± 210.9
Sulfide46.386.9 ± 121.4
150 mg q.d. (n = 13)Sulindac25.9126.7 ± 264.8
Sulfide33.372.1 ± 106.4
150 mg b.i.d. (n = 13)Sulindac39.865.0 ± 142.90.57
Sulfide61.9101.7 ± 137.40.77

NOTE: Too few detectable values for NAF sulfone to conduct comparison between dose groups.

  • *Two-sided Wilcoxon rank-sum test for difference between dose groups.