Table 3.

Change in serum hormones and growth factors (median, mean, and SD)

Variable or biomarkernPrestudyPoststudyDifferenceP (Wilcoxon)
Collected at time of RPFNA (days 1-10 of menstrual cycle)
    Estradiol (pg/mL)2297.5 (154 ± 117)102 (144 ± 90)1.29 (−10.8 ± 53.4)0.55
    Estradiol (nmol/L)220.36 (0.57 ± 0.43)0.38 (0.53 ± 0.33)0.00 (−0.04 ± 0.20)
    Bioavailable (free) estradiol (pmol/L)224.6 (6.3 ± 4.4)4.9 (6.4 ± 4.1)0.32 (0.12 ± 1.84)0.90
    SHBG, with estradiol (nmol/L)2280.2 (81.2 ± 28.6)67.9 (72.9 ± 26.3)−11.7 (−8.3 ± 30.1)0.031
Collected at days 20 to 24 of menstrual cycle
    IGF-I (ng/mL)44194 (201 ± 78)180 (196 ± 67)0.28 (−5.1 ± 47.8)0.48
    IGF-I (nmol/L)4425.3 (26.2 ± 10.1)23.4 (25.5 ± 8.7)0.04 (−0.66 ± 6.21)
    IGFBP-3 (ng/mL)445,854 (5,978 ± 1,009)5,672 (5,729 ± 1,022)−220 (−249 ± 790)0.029
    IGFBP-3 (nmol/L)44205 (209 ± 35)199 (201 ± 36)−7.7 (−8.7 ± 27.6)
    IGF-I/IGFBP-3 molar ratio440.12 (0.12 ± 0.04)0.12 (0.13 ± 0.03)0.001 (0.003 ± 0.029)0.65
    Progesterone (ng/mL)446.1 (8.0 ± 8.2)6.4 (8.8 ± 9.8)0.4 (0.8 ± 8.5)0.58
    Progesterone (nmol/L)4419.3 (25.5 ± 26.2)20.3 (28.0 ± 31.2)1.3 (2.5 ± 27.2)
    Testosterone (ng/mL)441.1 (1.6 ± 2.4)1.1 (1.6 ± 2.0)0.07 (0.00 ± 1.32)0.11
    Testosterone (nmol/L)443.7 (5.7 ± 8.3)3.8 (5.7 ± 7.0)0.25 (0.00 ± 4.57)
    Bioavailable (free) testosterone (pmol/L)4439.3 (59.8 ± 63.3)43.3 (73.9 ± 101.3)3.9 (17.2 ± 74.8)0.061
    SHBG (nmol/L)4476.9 (70.1 ± 25.5)70.9 (72.2 ± 30.6)0.82 (2.03 ± 23.5)0.99
    SECO (nmol/L)420.0 (0.62 ± 1.15)5.7 (33.7 ± 66.5)5.5 (32.8 ± 66.5)<0.001
    END (nmol/L)420.0 (0.69 ± 1.29)23.3 (84.3 ± 133.0)23.3 (83.7 ± 133.0)<0.001
    ENL (nmol/L)4211.1 (15.8 ± 17.4)99.2 (132.7 ± 120.3)74.8 (117.0 ± 117.7)<0.001
    Total lignans (nmol/L)4211.1 (16.8 ± 17.9)183.3 (248.8 ± 216.7)165.9 (233.5 ± 213.9)<0.001