Table 1

Characteristics of invasive breast cancers according to BRCA1/2 status

Tumor characteristicMutation status
BRCA1/2-negative (sporadic)BRCA1/2-positiveBRCA1-positiveBRCA2-positive
N (146)%N (73)%P*N (46)%P*N (27)%P*
Grade
 11410.141016.39614.63420.00
 27453.621219.67<0.0001717.07<0.0001525.000.0330
 35036.233963.932868.291155.00
 Data N/A8N/A12N/A5N/A7N/A
ER
 −3526.923661.023076.92630.00
 +9573.082338.98<0.0001923.08<0.00011470.000.7905
 Data N/A16N/A14N/A7N/A7N/A
PR
 −5945.383967.242873.681155.00
 +7154.621932.760.00711026.320.0029945.000.4759
 Data N/A161587
HER-2/neu by FISH
 −4669.702385.191482.35990.00
 +2030.30414.810.1909317.650.3746110.000.2676
 Data N/A80N/A46N/A29N/A17N/A
HER-2/neu by IHC
 03942.391341.941052.63325.00
 1+2325.001135.48736.84433.33
 2+1617.39619.350.2888210.530.2030433.330.4140
 3+1415.2213.2300.0018.33
 Data N/A54N/A42N/A27N/A15N/A
HER-2/neu expression IHC
 0 to 1+6267.392477.421789.470.0573758.33
 2+ to 3+3032.61722.580.33680210.53541.670.5321
 Data N/A54N/A42N/A27N/A15N/A

Abbreviations: FISH, fluorescent in situ hybridization; IHC, immunohistochemistry.

  • *Based on comparison to sporadic BRCA1/2-negative controls.

  • Comparison remained significant after Bonferroni correction.