Table 1

Selected characteristics of all patients, including baseline cardiovascular risk factors

Placebo (n = 184)DFMO/sulindac (n = 191)
Age (y)
 Mean ± SD61 ± 8.260 ± 8.6
 Range42-7841-79
Age >75 y, n (%)8 (4)7 (4)
Use of low-dose aspirin, n (%)69 (38)77 (40)
History of cardiovascular disease, n (%)*102/181 (56)108/186 (58)
History of high blood pressure or hypertension or medication taken, n (%)*72/181 (40)73/186 (39)
History of hyperlipidemia or medication taken, n (%)*55/181 (30)54/186 (29)
History of diabetes or medication taken, n (%)*17/181 (9)23/186 (12)
Current or prior cigarette smoker, n (%)*,25/99 (25)27/100 (27)
Risk score*,,:
 Low risk score, n (%)49/181 (27)55/186 (30)
 Moderate risk score, n (%)61/181 (34)54/186 (29)
 High risk score, n (%)71/181 (39)77/186 (41)

NOTE: P > 0.05 (not significant) for each of the above comparisons.

  • *The denominator is the number of subjects for whom information was recorded in either medical history form or concomitant medication form. Missing values are not included.

  • Self-reported information.

  • Risk score, derived from Solomon et al. (7): low—no known risk factors; moderate (one of the following)—age >75 y, HTN or medication taken, hyperlipidemia or medication taken, current or prior smoker, or use of low dose ASA; high—diabetes or medication taken, prior history of cardiovascular disease (coronary artery disease, myocardial infarction, congestive heart failure, cerebrovascular accident), or ≥2 risk factors from moderate category.