Table 3

Serum total bilirubin concentrations in participants stratified by UGT1A1 genotype, diet period, and day of sampling

Total bilirubin (μmol/L)
BasalSingle-dose cruciferousDouble-dose cruciferousCruciferous plus apiaceous
UGT1A1 *1/*1 (n = 29)
 Day 714.88 ± 1.54*a13.85 ± 1.37a14.88 ± 1.37a15.05 ± 1.37a
 Day 1115.05 ± 1.54a14.19 ± 1.37ab13.34 ± 1.20b14.02 ± 1.37ab
 Day 1415.73 ± 1.54a14.36 ± 1.37b14.02 ± 1.37b14.02 ± 1.37b
 Mean15.22 ± 1.37a14.19 ± 1.37b14.19 ± 1.20b14.36 ± 1.37ab
UGT1A1 *1/*28 (n = 36)
 Day 716.59 ± 1.54a16.59 ± 1.54a15.90 ± 1.54a15.73 ± 1.54a
 Day 1115.90 ± 1.54a15.56 ± 1.54ab14.36 ± 1.54bc14.19 ± 1.37c
 Day 1415.90 ± 1.54a15.56 ± 1.54ab15.05 ± 1.37ab14.31 ± 1.37b
 Mean16.07 ± 1.54a15.90 ± 1.54ac15.05 ± 1.37bc14.71 ± 1.37b
UGT1A1 *28/*28 (n = 5)
 Day 721.72 ± 3.25a19.32 ± 2.91ab16.59 ± 2.57b18.13 ± 2.74ab
 Day 1120.35 ± 3.08a18.81 ± 2.74ab17.78 ± 2.74ab15.39 ± 2.22b
 Day 1422.06 ± 3.25a16.07 ± 2.39b17.44 ± 2.74ab17.27 ± 2.57b
 Mean21.38 ± 2.91a17.96 ± 2.39b17.27 ± 2.39b16.93 ± 2.39b

NOTE: a, b, and c: diet means within a row not sharing a common superscript are significantly different as tested by ratio of means (P < 0.05).

  • *LS back-transformed means ± LS SE, adjusted for sex, baseline, and day 0 bilirubin concentrations.

  • Mean of three sampling days (7, 11, and 14).