Table 3.

ORs and 95% CIs for breast cancer risk by plasma 25-OHD levels

Plasma 25-OHD (ng/mL)Cases n (%)Controls n (%)Age-adjusted modelAdjusted model*
OR (95% CI)POR (95% CI)P
<20342 (33)302 (28)1.000.0031.000.004
20-29274 (27)287 (27)0.84 (0.67-1.05)0.80 (0.62-1.04)
30-39287 (28)295 (27)0.87 (0.69-1.08)0.83 (0.64-1.07)
≥40123 (12)191 (18)0.59 (0.44-0.77)0.56 (0.41-0.78)
ORtrend0.87 (0.80-0.95)0.0010.86 (0.78-0.94)0.002
As continuous variable per 5 ng/mL increment1,0261,0750.94 (0.91-0.97)<0.0010.93 (0.90-0.97)<0.001
  • *Adjusted for age, race, age of menarche, age of first birth, parity, breastfeeding history, menopausal status, use of hormone replacement therapy, first-degree family history of breast cancer, history of benign breast disease, BMI, physical activity, and season of blood draw.