Table 3.

Individual pharmacokinetic parameters of aflatoxin equivalents

Aflatoxin aloneWith ChlaWith CHL
Subject 1Cmax (pg/mL)1.02 ± 0.170.44 ± 0.14*0.86 ± 0.09
Tmax (h)0.99 ± 0.020.83 ± 0.151.86 ± 0.33*
t1/2α (h)2.06 ± 0.283.15 ± 1.502.93 ± 1.46
ka (absorption rate constant)4.78 ± 0.01 (2)3.97 ± 0.45 (2)2.54 ± 0.60
AUC0-t (h*pg/mL)22.57 ± 9.9310.27 ± 3.4027.20 ± 2.69
AUC0-2411.94 ± 2.514.97 ± 1.61*12.55 ± 1.25
Subject 2Cmax (pg/mL)0.97 ± 0.150.73 ± 0.130.74 ± 0.26
Tmax (h)0.92 ± 0.511.67 ± 0.774.16 ± 3.34
t1/2α (h)4.39 ± 2.838.26 (1)7.75 ± 2.66 (2)
ka (absorption rate constant)7.76 ± 1.13 (2)3.28 (1)0.97 ± 0.47*
AUC0-t (h*pg/mL)29.00 ± 1.0521.87 ± 3.7123.83 ± 8.30
AUC0-2413.40 ± 0.779.60 ± 3.0211.15 ± 3.51
Subject 5Cmax (pg/mL)0.83 ± 0.120.50 ± 0.130.49 ± 0.07
Tmax (h)1.16 ± 0.292.35 ± 0.792.17 ± 0.77
t1/2α (h)3.74 ± 0.263.67 ± 1.142.96 (1)
ka (absorption rate constant)3.43 ± 0.402.91 ± 1.431.27 ± 1.08
AUC0-t (h*pg/mL)25.23 ± 5.3414.10 ± 4.7717.77 ± 3.80
AUC0-2411.88 ± 2.076.42 ± 1.568.17 ± 1.47

NOTE: 1 and 2 denotes n = 1 and n = 2 respectively, because either two or one of the replicate runs could not be fit to a two compartment model. Mean and SD over (n =) 3 replicate runs except where noted in parentheses.

  • *P < 0.01 vs Aflatoxin alone (Dunnett adjusted).

  • P < 0.05.