Table 1

Summary of activity of the derivatives compared with deguelin

FormulaDeguelinSH-02SH-03SH-09SH-14
C23H22O6C23H24O6C23H24O6C23H22O7C23H25O7
Docking in ATP pocket+++++++++++
Hif-1++++++++++
Cytotoxicity++++++++++
Apoptosis/RPPA++++++ND+++
Hsp90/RPPA++++++ND++
mTOR/RPPA+++++ND++
Src/STAT Activation/RPPA+++++++++ND+
Aqueous solubility (╬╝mol/L)37.69NDNDND62.08