Table 2

Effect of kava on liver in A/J mice

GroupAbsolute liver weight (g ± SD)Relative liver weight (% of body weight, mean ± SD)Liver enzymatic activities
ALT ± SDAST ± SDGGT ± SD
1 (untreated control)1.50 ± 0.145.91 ± 0.6189.8 ± 6.9323 ± 487.0 ± 0
2 (carcinogens alone)1.73 ± 0.286.93 ± 1.29*99.7 ± 26.0408 ± 667.0 ± 0
3 (30-wk kava alone)1.46 ± 0.216.04 ± 0.8683.1 ± 6.1354 ± 127.0 ± 0
4 (carcinogens and 30-wk kava)1.42 ± 0.206.07 ± 0.85192 ± 154501 ± 2017.0 ± 0
5 (carcinogens and 8-wk concurrent kava)1.56 ± 0.276.38 ± 1.18154 ± 123439 ± 757.0 ± 0
6 (carcinogens and 22-wk post-carcinogen kava)1.55 ± 0.156.38 ± 0.65150 ± 143385 ± 987.5 ± 1.0

NOTE: The liver weight and enzymatic activities were measured at the time of sacrifice. The comparison is between groups 1 and 2, groups 1 and 3, and group 2 with groups 4, 5, or 6. The only comparisons that showed statistically significant difference are the liver weights of group 1 versus group 2 and group 2 versus group 4. No other comparison showed any statistically significant difference, including liver weight and the enzymatic activities of the three enzymes.

  • *P = 0.0019.

  • P = 0.012.