Table 1

Study characteristics

First authorStudy locationYear*Study typeHP DxHP+ definitionEACESCCMatched/adjusted§Controls
CaseControlCaseControl
HP+CagA+HP+CagA+HP+CagA+HP+CagA+
1. Talley (42)USA1991ClinSHPSe+20/4196/252No/yesAsymptomatic volunteers and patients with benign esophageal, lung, or musculoskeletal disorders
2. Oberg (35)USA1999ClinHHist+5/3732/229No/noPatients with foregut symptoms and benign diseases
3. Peek (36)USA1999ClinS, HHPSe+ or Hist+11/303/3020/4825/48No/noPatients endoscoped for reasons other than GERD or Barrett's
4. Vieth (45)Germany2000ClinHHist+66/138468/712No/noPatients with non–ulcer dyspepsia and no endoscopic signs of GERD
5. Weston (48)USA2000ClinHHist+3/2096/217No/noPatients with GERD symptoms but no Barrett's esophagus
6. El Omar (27)USA2003PopSHPSe+35/1085/6884/21046/22431/537/2684/21046/224Yes/noMatched to cases for age, sex, and study center
7. Wu AH (50)USA2003PopSHPSe+ (HPSe+ or CagA+)49/80 (52/80)18/80230/356 (249/356)106/356Yes/yesMatched to cases for age, sex, neighborhood of residence, and race
8. Wang KX (46)China2003NRSHPSe+33/63145/310NR/noHealthy subjects
9. Ye (53)Sweden2004PopSHPSe+ (HPSe+ or CagA+)18/97 (47/97)42/97198/499 (304/499)293/49932/85 (64/85)63/85198/499 (304/499)293/499Yes/yesRandomly selected population-based controls, frequency matched to EAC cases for age and sex
10. de Martel (23)USA2005PopSHPSe+19/519/1874/15044/71Yes/yesRandomly selected from the study cohort, matched to cases for age, sex, race, and study site
11. Wu DC (52)Taiwan2005PopSHPSe+28/12774/171No/yesParents of children randomly selected from the study area
12. Wang Z (47)**China2006PopSHPSe+?/107?/107Yes/yesNeighborhood controls, randomly selected and matched to cases for age and sex
13. Siman (41)Sweden2007PopSHPSe+ (HPSe+ or CagA+)4/12 (7/12)6/1224/47 (35/47)32/4715/37 (24/37)24/3768/129 (87/129)82/129Yes/yesRandomly selected from the study cohort, matched to cases for age, sex, and date of enrollment
14. Kamangar (33)China2007PopSHPSe+ (HPSe+ or CagA+)231/335 (254/335)178/335662/992 (727/992)552/992No/yesRandomly selected from the baseline participants in the study cohort
15. Anandasabapathy (20)USA2007ClinHHist+4/2510/30No/noBarrett's patients with no dysplasia
16. Iijima (31)Japan2007ClinS, H,UHPSe+, Hist+, or U+60/7356/73Yes/yesEndoscoped patients with no localized lesion, matched to cases for age and sex
17. Derakhshan (25)Iran2008ClinSHPSe+9/1928/38Yes/yesDyspeptic patients with no peptic ulcer or tumor in their endoscopy
18. Fruh (28)USA2008ClinSHPSe+36/10029/10043/10130/101Yes/yesHealthy GERD-free, non–blood-related family members and friends of other cancer/surgical patients
19. Anderson (21)Ireland2008PopSHPSe+55/12357/123157/253150/253Yes/yesRandomly selected population-based controls, frequency matched to EAC cases for age and sex

Abbreviations: Clin, clinic based; Pop, population based; NR, not reported; HP Dx, HP detection method; S, serology; H, histology; U, rapid urease test.

  • *Publication year.

  • Definition for H. pylori positivity: Hist+, positive histologic examination of tissue samples; HPSe+, seropositivity for antibodies to whole cell; CagA+, sero-positivity for antibodies to CagA; U+, positive rapid urease test.

  • Number of subjects with a positive test/total number of subjects.

  • §Group- or individual-matching of controls to cases for age/reporting adjusted ORs for the association between H. pylori or CagA and cancer.

  • EAC cases include Barrett's with high-grade dysplasia.

  • Because the authors reported that there was no difference in age and gender between cases and controls, this study was analyzed as a matched study.

  • **H pylori–positive numbers by case status were not reported.