Table 1

Genes up-regulated or down-regulated in mouse colonic epithelial cells after zebularine treatment

Biological processGene symbolProbe IDDescription
(A) Genes up-regulated in colonic epithelial cells after chronic zebularine treatment of the Min mice
Peptide cross-linkingTgm21455900_X_ATtransglutaminase 2
1433428_X_AT
1437277_X_AT
DigestionPpy1420440_ATpancreatic polypeptide
Akr1b101448894_ATaldo-keto reductase family 1, member B10 (aldose reductase)
Fabp21418438_ATfatty acid binding protein 2, intestinal
Acute-phase responseReg3a1448290_ATregenerating islet-derived 3α
1416297_S_AT
Reg3g1448872_ATregenerating islet-derived 3 γ
Regulation of cell adhesionTgm21455900_X_ATtransglutaminase 2
1433428_X_AT
1437277_X_AT
Arginine metabolismDdah11429298_ATdimethylarginine dimethylaminohydrolase 1
Otc1420525_A_ATornithine carbamoyltransferase
Urea cycle intermediate metabolismDdah11429298_ATdimethylarginine dimethylaminohydrolase 1
Otc1420525_A_ATornithine carbamoyltransferase
Aldehyde metabolismAldh1a11416468_ATaldehyde dehydrogenase 1 family, member A1
Akr1b101448894_ATaldo-keto reductase family 1, member B10 (aldose reductase)
(B) Genes down-regulated in colonic epithelial cells after chronic zebularine treatment of the Min mice
Peptide cross-linkingTgm31440150_ATtransglutaminase 3
DigestionSlc15a11419343_ATsolute carrier family 15 (oligopeptide transporter), member 1
Ctse1418989_ATcathepsin E
Regulation of cell adhesionLama31427512_A_ATlaminin, α3
Iron ion homeostasisSlc40a11417061_ATsolute carrier family 40 (iron-regulated transporter), member 1
1447227_AT

NOTE: Min mice were given 0.2 mg/mL zebularine dissolved in 3% sucrose-water daily for 113 ± 3 d. Mice were sacrificed on day 120. RNA from colonic epithelial cells was subjected to microarray analysis and analyzed using S-score algorithm (P < 10−5). An L2L array was used to obtain biological processes that were significantly affected (29).