Table 2.

Gene expression changes detected by statistical methods

Repeated measures ANOVA a
Folate statusDepletionDepletionRepletion
Time point, wk4812 (vs. 8)
No. of Genes1,585
Upregulated806999365
720 b
Downregulated7795841,209
500 b
Repeated measures ANOVA c
Folate status Supplementation
Time point, wk48
No. of Genes1,001
Upregulated522477
306 b
Downregulated479524
308 b
Paired t test baseline vs. 8-wk supplementation c
No. of Genes2,073
Upregulated642
Downregulated1,431
  • aAdjusted by Benjamini–Hochberg Multiple Correction Test.

  • bModulated at both 4 and 8 weeks.

  • cUnadjusted analysis.