Table 1.

Biochemical properties of fluorinated indomethacin and celecoxib derivatives

Table 1.

NOTE: The IC50s for inhibition of purified ovine COX-1, human COX-2, or COX-2 in LPS activated macrophage-like RAW264.7 cells.

  • aAssays were conducted as described in Materials and Methods. Compounds that are poor inhibitors of COX-2 in the purified enzyme assay were not tested (N.T.) in intact cells.