Table 1.

Characteristics of lung adenocarcinoma patients and controls used for the gene expression analysis from peripheral whole blood, Italy, 2002–2005

Discovery setValidation set
ControlsCasesPaControlsCasesPa
Sex0.930.48
 Male403711167
 Female40361915
Age0.730.46
 40–442221
 45–493222
 50–547755
 55–591191614
 60–6413132715
 65–6913163117
 70–7421193318
 75–791051410
Cigarette smoking0.71
 Never212200
 Former322700
 Current272413082
Cumulative pack-years0.440.76
 Below median31236340
 Above median28286739
 Missing0003
 Mean (SD)33.7 (21.9)34.7 (20.5)51.2 (21.9)50.1 (24.4)
Cigarette per day0.930.56
 Below median29254826
 Above median30258253
 Missing0103
 Mean (SD)17.9 (10.1)17.5 (9.1)21.1 (7.8)21.4 (9.3)
Tumor stageb
 IA1136
 IB1546
 IIA30
 IIB150
 IIIA90
 IIIB80
 IV120
Tumor grade
 168
 22828
 33338
 Missing66
  • aP value based on a 2-sided Wald test.

  • bStage definition was based on the International System for Staging Lung Cancer by the AJCC and UICC, Mountain CF 1997.