Table 3.

Crude and adjusted ORs and 95% CIs for mtDNA copy number and pancreatic cancer risk

mtDNA copy number
Q1Q2Q3Q4Q5Continuous
≤94.6>94.6–≤113.3>113.3–≤132.8>132.8–≤158.0>158.0PtrendaORb
n (cases/controls)38/13339/13330/14243/13053/118203/656
Crude1.00 (ref)1.03 (0.62–1.71)0.74 (0.43–1.26)1.16 (0.70–1.91)1.57 (0.97–2.55)0.061.13 (1.05–1.22)
Adjustedc1.00 (ref)1.04 (0.63–1.74)0.75 (0.44–1.28)1.22 (0.74–2.02)1.64 (1.01–2.67)0.041.14 (1.06–1.23)
Cases diagnosed <7 years after whole blood collection n (cases/controls)38/11823/13013/14221/13323/1331,18/656
Crude1.00 (ref)0.91 (0.48–1.73)0.53 (0.26–1.10)1.02 (0.55–1.91)1.86 (1.05–3.31)0.051.13 (1.05–1.22)
Adjustedc1.00 (ref)0.78 (0.38–1.59)0.60 (0.28–1.27)1.16 (0.59–2.27)2.14 (1.16–3.96)0.011.21 (1.10–1.34)
Cases diagnosed ≥7 years after whole blood collection15/11820/13017/14218/13315/13385/656
Crude1.00 (ref)1.20 (0.58–2.48)1.06 (0.51–2.21)1.36 (0.67–2.78)1.13 (0.53–2.40)0.061.03 (0.92–1.16)
Adjustedc1.00 (ref)1.27 (0.61–2.63)1.08 (0.52–2.27)1.37 (0.67–2.81)1.14 (0.53–2.45)0.671.05 (0.93–1.18)
  • aTest for trend calculated using the median value for each mtDNA copy number quintile.

  • bContinuous variables are presented based on a 21 unit change, which corresponds to the average unit change within quintiles 2–4.

  • cAdjusted for age, smoking duration, smoking intensity, diabetes.