Table 3.

Multivariable-adjusteda estimated RRs of colon and rectal cancer according to MetS definitions and individual MetS components, follow-up 1992–2003

Colon cancerRectal cancer
RR (95% CI)AllMenWomenPbAllMenWomenPb
Components of MetS
 N, cases/controls231/175106/67125/108127/10573/6154/44
AO (high WC) by NCEP/ATPIII1.55 (1.19–2.02)2.07 (1.36–3.14)1.32 (0.93–1.87)0.061.34 (0.96–1.87)1.21 (0.75–1.97)1.68 (0.97–2.92)0.67
 N, cases/controls438/364208/165230/199239/231141/13198/100
AO (high WC) by IDF1.68 (1.31–2.15)1.78 (1.22–2.60)1.63 (1.15–2.31)0.531.07 (0.79–1.45)1.16 (0.75–1.80)1.09 (0.67–1.79)0.64
 N, cases/controls151/12281/6970/5394/8772/6122/26
Elevated TG1.36 (0.95–1.68)1.11 (0.73–1.67)1.44 (0.95–2.18)0.531.00 (0.70–1.44)0.98 (0.61–1.59)1.02 (0.52–1.98)0.54
 N, cases/controls176/13672/48104/8878/8743/4335/44
Reduced HDL-C1.36 (1.04–1.77)1.60 (1.02–2.49)1.21 (0.86–1.70)0.370.91 (0.63–1.32)1.21 (0.70–2.12)0.83 (0.48–1.44)0.27
 N, cases/controls442/413218/208224/205261/251152/147109/104
Elevated BP1.26 (0.98–1.61)1.25 (0.86–1.83)1.40 (0.98–1.98)0.921.07 (0.77–1.50)1.02 (0.61–1.70)1.25 (0.77–2.03)0.99
 N, cases/controls356/264178/139178/125205/161116/10289/59
AGM2.14 (1.64–2.77)1.85 (1.28–2.66)2.80 (1.86–4.22)0.162.07 (1.45–2.96)1.66 (1.00–2.73)3.20 (1.78–5.77)0.12
Definitions of MetS
 N, cases/controls229/144108/74121/70121/9475/6046/34
MetS by NCEP/ATPIII1.91 (1.47–2.42)1.70 (1.15–2.50)2.25 (1.55–3.26)0.491.45 (1.02–2.06)1.35 (0.83–2.21)2.03 (1.14–3.62)0.80
 N, cases/controls280/188140/94140/94144/12487/7757/47
MetS by IDF1.91 (1.48–2.46)1.97 (1.35–2.88)2.02 (1.41–2.88)0.841.28 (0.93–1.76)1.16 (0.75–1.78)1.83 (1.05–3.18)0.66
 N, cases/controls306/205150/107156/98155/13397/8458/49
MetS by harmonized criteria2.00 (1.56–2.56)1.84 (1.28–2.66)2.33 (1.63–3.33)0.731.31 (0.95–1.79)1.24 (0.80–1.90)1.70 (0.98–2.93)0.82

NOTE: For all RRs, reference category was no presence of the characteristic. The presented RR estimates refer to dichotomized variables. The numbers for the cases and controls refer to the presence of MetS components or definitions.

Abbreviations: AO, abdominal obesity; AGM, abnormal glucose metabolism; WC, waist circumference; TG, tryglicerides; HDL-C, high-density lipoprotein cholesterol; BP, blood pressure; MetS, metabolic syndrome.

  • aResults based on conditional logistic regression (matching factors: age, sex, study center, follow-up time since blood collection, time of the day at blood collection and fasting status; women were further matched by menopausal status and phase of menstrual cycle at blood collection; and postmenopausal women were matched by HRT use) with adjustment for smoking status, education, alcohol consumption, physical activity, fiber intake, consumption of fruits and vegetables, red and processed meat, fish, and shellfish.

  • bP for difference by sex calculated by using interaction terms of MetS definitions and components (categorical), multiplied by the stratum variable in the multivariable-adjusted model.