Table 1.

Genotyped mouse phase I and phase II human orthologuesa

Phase I—CypPhase II–UgtPhase II–Gst
HumanMurineHumanMurineHumanMurine
CYP2A6b, c, CYP2A7Cyp2a4,Cyp2a5UGT1A4dUgt1a5GSTA3Gsta3
CYP2F1bCyp2f2UGT1A1Ugt1a1GSTA4Gsta4
CYP2S1Cyp2s1UGT1A6Ugt1a6aGSTP1Gstp1
CYP4B1Cyp4b1UGT2B4Ugt2b1GSTM2Gstm2
NF (2D6 superfamily)cCyp2c29NFUgt2b5GSTM3Gstm3
NF (3A5 superfamily)bCyp3a11UGT2B10dUgt2b34GSTM1/M5Gstm1
CYP8B1Cyp8b1UGT2B15Ugt2b35
UGT2A3Ugt2a3
UGT1A9dUgt1a9
NFUgt1a10
UGT2B15Ugt2b36

NF, no orthologue found.

  • aBlake JA and colleagues (50).

  • bIsoforms found to bioactivate NNK to keto alcohol.

  • cIsoforms found to bioactivate NNK to keto acid.

  • dIsoforms found to glucuronidate NNAL.