Table 3.

Fatty acid levels in benign and malignant prostate tissue membranes from radical prostatectomy specimens

Benign prostate tissueMalignant prostate tissue
Fatty acidsWestern diet (n = 18)Fish oil (n = 19)PWestern diet (n = 7)Fish oil (n = 6)P
mean ± SEMmean ± SEMmean ± SEMmean ± SEM
Palmitic30.42 ± 0.8730.02 ± 0.490.6930.05 ± 0.3831.06 ± 0.360.08
Palmitoleic1.43 ± 0.381.33 ± 0.240.820.81 ± 0.110.75 ± 0.120.73
Stearic18.74 ± 1.0918.32 ± 0.990.7820.07 ± 0.7721.13 ± 0.680.33
Oleic25.63 ± 1.7826.90 ± 1.550.5923.59 ± 1.3222.47 ± 1.460.58
LA (18:2, n-6)11.23 ± 0.7510.50 ± 0.570.4412.11 ± 0.469.73 ± 0.480.005
α-linolenic (n-3)0.67 ± 0.130.57 ± 0.080.500.18 ± 0.020.18 ± 0.020.98
Eicosadienoic (n-6)0.72 ± 0.070.72 ± 0.130.980.82 ± 0.061.00 ± 0.170.33
AA (20:4, n-6)7.11 ± 0.585.85 ± 0.440.098.44 ± 0.607.32 ± 0.680.24
EPA (20:5, n-3)0.10 ± 0.020.42 ± 0.05<0.0010.07 ± 0.010.44 ± 0.07<0.001
Docosapentaenoic (n-3)0.70 ± 0.070.81 ± 0.330.330.85 ± 0.060.90 ± 0.080.58
DHA (22:6, n-3)3.25 ± 0.304.55 ± 0.380.0113.01 ± 0.135.03 ± 0.39<0.001
Total n-618.34 ± 0.5016.35 ± 0.410.00320.5 ± 0.5717 ± 0.860.005
Total n-34.72 ± 0.386.35 ± 0.500.0144.11 ± 0.156.54 ± 0.43<0.001
n-6/n-34.48 ± 0.523.07 ± 0.420.0425.02 ± 0.462.68 ± 0.24<0.001

NOTE: The fatty acids were measured in postintervention radical prostatectomy tissue. Fatty acid content is expressed as a percent of total fatty acids. n-3, omega-3; n-6, omega 6; LA, linoleic acid; AA, arachidonic acid; EPA, Eicosapentaenoic acid, DHA, docosahexaenoic acid.