Table 2.

Associations of ODC genotypes with risk of adenoma recurrence, Aspirin/Folate Polyp Prevention Study, 1994–2001

SNPPositionaLocationCall ratePHWEMAFRR (95% CI)cPQd
rs1300091610,490,3043′ flanking0.9950.090.4490.89 (0.80–0.99)0.0310.07
rs1169491110,490,6493′ flanking0.9910.960.1061.29 (1.10–1.51)0.0020.027
rs243041910,493,2393′ flanking1.0000.590.2471.09 (0.97–1.24)0.150.27
rs243042010,493,6773′ flanking1.0000.860.3241.17 (1.05–1.31)0.0050.027
rs1092966910,493,8833′ flanking0.9970.610.1151.22 (1.04–1.43)0.0170.054
rs2836243410,496,0953′ flanking1.0000.820.1830.94 (0.81–1.08)0.360.52
rs81816210,496,6753′ flanking1.0000.440.3020.86 (0.76–0.97)0.0120.048
rs104950010,498,418Exon 12b1.0000.570.0411.38 (1.10–1.73)0.0050.027
rs2836241610,498,720Intron 110.9960.100.0670.85 (0.67–1.07)0.180.29
rs755997910,500,130Intron 80.9850.610.3471.05 (0.93–1.17)0.440.59
rs2836238010,504,231Intron 10.9990.830.1031.04 (0.88–1.23)0.670.77
rs2302615e10,505,589Intron 10.9980.500.2541.02 (0.90–1.15)0.80
rs172814810,508,9085′ flanking0.9990.790.4510.92 (0.83–1.02)0.120.24
rs88581510,509,0795′ flanking0.9920.320.2140.96 (0.84–1.09)0.510.63
rs288421110,509,6235′ flanking1.0000.700.0771.01 (0.83–1.23)0.890.94
rs235755110,509,6315′ flanking1.0000.730.3421.13 (1.01–1.27)0.0290.07

Abbreviations: HWE, Hardy–Weinberg equilibrium; RR, relative risk.

  • aLocation on chromosome 2p25 according to NCBI Human Genome Map Build 36.

  • bThe substitution is synonymous.

  • cPer-allele relative risk and Wald test P value using an additive genetic model adjusted for age and sex.

  • dFDR q values (27).

  • ePreviously genotyped SNP, not included in multiple testing correction (n = 765; ref. 17).