Table 1.

Clinical and pathological demographics of Lynch syndrome–associated polyps

Adenomatous polyps
SubjectSexAge, yPolyp size, mmPolyp locationGermline mutationMSI statusMMR IHC results
1M51n/aDistalMSH2MSSIntact
2M53n/aDistalMSH2MSSIntact
3F583DistalMSH6MSSIntact
4F4510DistalMSH2MSI-HAbnormal
512ProximalMSI-HAbnormal
588DistalMSI-HAbnormal
6115DistalMSI-HAbnormal
6M313DistalMLH1MSSIntact
7M442ProximalMLH1MSSIntact
462DistalMSSaAbnormala
10M535ProximalMLH1MSI-HAbnormal
6210ProximalMSI-HAbnormal
694DistalMSI-HAbnormal
11M386DistalMSH2MSSaAbnormala
394DistalMSI-HAbnormal
15F5110DistalMSH2MSI-HAbnormal
5115DistalMSI-HAbnormal
16F403ProximalMSH2MSI-LIntact
403DistalMSI-LIntact
233M573ProximalMSH2MSI-HAbnormal
242F408DistalMLH1MSSaAbnormala
408DistalMSSIntact
279F522ProximalMSH2MSSIntact
522DistalMSSIntact
524DistalMSSIntact
525ProximalMSSIntact
402M5010DistalMSH2MSI-HAbnormal
439M274ProximalMSH2MSSIntact
787F492ProximalMLH1MSI-HAbnormal
867M592DistalMSH2MSI-Hn/a
901F591ProximalMLH1MSI-LIntact
992F353ProximalMLH1MSSaAbnormala
353ProximalMSSaAbnormala
1,016F462ProximalMSH6MSI-HaIntacta
462ProximalMSSIntact
462DistalMSSIntact
1,024M237ProximalMSH2MSSIntact
Hyperplastic polyps
4F482DistalMSH2MSSIntact
613DistalMSSIntact
5F673DistalMLH1MSI-HaIntacta
9F432DistalMLH1MSI-LIntact
10M574DistalMLH1MSSIntact
12F513DistalMLH1MSSn/a
16F382DistalMSH2MSI-LIntact
403DistalMSI-LIntact
242F402DistalMLH1MSSIntact
251F262DistalMSH2MSSIntact
267DistalMSSIntact
386F502DistalMSH2MSSIntact
503DistalMSSIntact
439M274ProximalMSH2MSSIntact
607F255ProximalMSH2MSSIntact
732M493DistalMSH2MSSIntact
821M674DistalMSH2MSSIntact
858F391ProximalMSH2MSSn/a
929M354ProximalMSH2MSSIntact
947F513DistalMSH2MSSIntact
992F353DistalMLH1MSSIntact
1,024M231DistalMSH2MSSIntact
1,032F262DistalMSH2MSSIntact
Sessile Serrated Polyps
8F455ProximalMLH1MSSIntact
16F3810ProximalMSH2MSI-HaIntacta
  • ↵aDiscordance between MSI and IHC results. n/a = not available.