Table 2.

NFS according to clinical and immunohistologic features

NFS
Univariate analysisMultivariate analysis
VariablesMedian, y5-y survival rate (95% CI)PHR (95% CI)P
Age, y<0.00010.011
 <641095 (72–99)
 ≥64526 (7–51)7.4 (1.6–34)
Sex0.4658
 MaleNR77 (54–90)
 Female1051 (23–73)
Number of polyps0.4064
 11073 (51–87)
 2–4756 (27–78)
Size of polyps (largest diameter, mm)0.06370.329
 <3NR76 (47–90)
 3–6760 (35–78)1.5 (0.79–2)
Localization0.13780.799
 Proximal colon543 (10–73)
 Distal colon1074 (54—86)1.1 (0.3–4)
Expression of progastrin0.001<0.0001
 No/low expression (<10%)NR100 (NC)
 Moderate expression (10%–50%)1084 (50–96)NC
 High expression (>50%)538 (15–61)1.6e09 (4e09–7e10)

NOTE: NFS among patients with colonic hyperplastic polyps who had a colonoscopic follow-up. Multivariate analysis was conducted using a Cox model including all variables with a P value <0.20 in the univariate analysis. Final model was obtained after backward stepwise selection, keeping variables with a P value <0.05. 95% CI was calculated for all 5-year survival values.

Abbreviations: NC, not calculable; NR, Not reached.